논문검색
Author Kyoung-Hwan Lee, M.D., Yong Jai Park, M.D., Eun Sun Kim, M.D., Hui Jeong Hwang, M.D., Byoung Yong Shim, M.D. and Hoon-Kyo Kim, M.D.
Place of duty Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea
Title Hypersensitivity Reactions to Oxaliplatin
Publicationinfo Cancer Res Treat 2006 Dec; 038(04): 240-244.
Key_word Hypersensitivity, Chemotherapy, Oxaliplatin
Full-Text
Abstract Oxaliplatin is a third-generation platinum compound that is used as a single agent and in combination with fluorouracil (5-FU) to treat colorectal and gastric carcinoma. The patients treated with oxaliplatin may develop hypersensitivity and idiosyncratic reactions, although these complications are known to be rare. We report here on two patients who suffered with metastatic colorectal cancer and who underwent palliative combination chemotherapy with oxaliplatin; they then developed hypersensitivity reactions to oxaliplatin. The first case had an anaphylatic reaction immediately after the beginning of the 7th to 8th cycle infusion of oxaliplatin. The second case developed repeated febrile episodes from the 4th to 8th cycles of oxaliplatin infusion. With the increasing use of oxaliplatin in clinical practice, we are now encountering an increasing incidence of suspected hypersensitivity reactions. Physicians should keep their eyes wide open and carefully observe for the clinical manifestations of these hypersensitivity reactions. (Cancer Res Treat. 2006; 38:240-241)
출판정보 대한암학회지 2006 Dec; 038(04): 240-244.